AFM Uncompromised

Minimal Hammerhead Ribozymes with Uncompromised Catalytic Activity.

We report here that a single additional trans-Hoogsteen base-pairing interaction in the minimal hammerhead ribozyme transforms an RNA sequence possessing typically modest catalytic activity into one possessing greatly enhanced catalytic activity that is instead typical of full-length natural hammerhead RNAs that have additional extensive tertiary contact interactions. Formation of this addition...

Coincident cytomegalovirus infection and toxoplasmosis in an uncompromised host.

Japan AFM roadmap 2006

This article reviews recent progress in Japan in the techniques and applications of dynamic mode atomic force microscopy (AFM), specifically focusing on three topics: (1) mechanical discrimination of intermixed two-atom species and their manipulation by frequency modulation (FM) AFM under ultrahigh vacuum; (2) sub-molecular and atomic-resolution imaging in liquids by FM-AFM; and (3) high-speed ...

Measuring AFM images

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Characterisation of tissue factor-bearing extracellular vesicles with AFM: comparison of air-tapping-mode AFM and liquid Peak Force AFM

INTRODUCTION Extracellular vesicles (EVs) are shed from cells and carry markers of the parent cells. Vesicles derived from cancer cells reach the bloodstream and locally influence important physiological processes. It has been previously shown that procoagulant vesicles are circulating in patients' fluids. These EVs are therefore considered as promising biomarkers for the thrombotic risk. Becau...